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Or HaChaim on Leviticus 19:26/אור החיים על ויקרא י״ט:כ״ו

אלֹא תֹאכְלוּ עַל הַדָּם סָמַךְ הַכָּתוּב מִצְוָה זוֹ לְמִצְוַת עָרְלָה, לִרְמֹז מַה שֶׁאָמְרוּ זִכְרוֹנָם לִבְרָכָה (מדרש תלפיות, בראשית רבה כא:ז) כִּי אָדָם הָרִאשׁוֹן חָטָא בַּאֲכִילַת עֵץ הַדַּעַת קֹדֶם זְמַן הֶתֵּרוֹ, שֶׁהוּא בְּחִינַת עָרְלָה, שֶׁאִם הָיָה מַמְתִּין עַד לֵיל שַׁבָּת קֹדֶשׁ הָיָה מְקַדֵּשׁ עַל הַיַּיִן, וְזֶה הוּא סוֹד דִּבְרֵיהֶם זִכְרוֹנָם לִבְרָכָה שֶׁאָמְרוּ (סנהדרין לח:) אָדָם מוֹשֵׁךְ בְּעָרְלָתוֹ הָיָה, זוֹ הִיא עָרְלָתוֹ, וְהוּא מַה שֶׁאָמַר הַכָּתוּב סָמוּךְ לְאַזְהָרַת ״וַעֲרַלְתֶּם עָרְלָתוֹ״ – לֹא תֹאכְלוּ, פֵּרוּשׁ, מִפְּרִי עָרְלָה, עַל הַדָּם, פֵּרוּשׁ, עַל סִבַּת הַדָּם, כִּי זוֹ סִבָּה לְכָל שְׁפִיכוּת דָּמִים, דַּם אָדָם וְדַם זַרְעִיּוֹתָיו. וְיֵשׁ לְךָ לָדַעַת כִּי סִבַּת הָעֲרָלוֹת וְעִקָּרָם זֶה מְקוֹרָם, שֶׁזּוּלַת חֵטְא אָדָם לֹא הָיְתָה עָרְלָה בָּעוֹלָם לֹא שֶׁל צוֹמֵחַ וְלֹא שֶׁל בַּעֲלֵי חַיִּים.
1 לא תאכלו על הדם, "You shall not eat with the blood;" Bereshit Rabbah 21,7 say that the reason that this commandment appears next to the prohibition of ערלה is an allusion to Adam who had eaten from the tree of knowledge before its period of being ערלה had expired. [the other trees had been expressly permitted by G'd so that that prohibiton was overridden. Ed] According to the Midrash, all Adam had to do was to wait until the advent of the Sabbath. He would have been permitted to recite the benediction over wine; [according to the view that the fruit of the tree of knowledge were grapes. Ed.] This is the mystical dimension of the statement in Sanhedrin 38 that אדם מושך בערלתו היה, that "Adam was pulling at his ערלה." The word refers to the as yet not permitted fruit; Adam was too impatient. This is why the Torah writes next to the commandment וערלתם ערלתו, "do not eat with the blood," i.e. "do not eat of the fruit of the tree which is still ערלה because of the blood," i.e. all bloodshed in the world originated when Adam ate from that tree prematurely. We may extrapolate from this that had it not been for Adam's failure at the time there never would have been such a prohibition as the one described in our paragraph. Neither plants nor animals would have become restricted to man at all, either temporarily or permanently.