Sforno on Genesis 4:24/ספורנו על בראשית ד׳:כ״ד

1ולמך שבעים ושבעה. My anguish over what I have done will be many times greater than the anguish of Kayin who had been condemned to be a constant fugitive on the earth. 'כי שבעתים יוקם קין וגו, for if Kayin’s punishment was indeed great, my punishment for having killed my son will be many times greater. [he referred to the anguish he suffered over what he had done, not to the punishment imposed upon him externally, as retribution. Ed.]