Or HaChaim on Genesis 32:33/אור החיים על בראשית ל״ב:ל״ג

1 על כן לא יאכלו בני ישראל את גיד הנשה. This is why the children of Israel do not eat the disjointed sinew, etc. This sinew was dislocated from its holy origin and became subject to dominance by the קליפה ["external forces" in the scheme of the emanations, Ed.]. G'd forbade anything which has thus become defiled wherever it appears. There is a mystical element in this. This sinew does not have a taste, an allusion to its originating in the "external forces." The reason is that it had been uprooted from a holier source.