Sforno on Genesis 32:26/ספורנו על בראשית ל״ב:כ״ו

1לא יכול לו, seeing that most of Yaakov’s striving was oriented toward G’d and heavenly concerns. Both his thinking and his conversation had G’d and His will as its focus.

2ויגע he informed him that in the future, i.e. כף ירכו, many of his offspring would become guilty of sins against G’d. While this troubled Yaakov he momentarily digressed from his concentration on G’d so that the angel could inflict an injury upon him during his lapse of concentration.